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Friday, June 23 • 2:30pm - 2:42pm
Exploring Evolutionary Dynamics of Communications in Bacteria Using Julia

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Many species of bacteria are able to collectively sense and respond to their environment. This communication form known as quorum-sensing (QS) can be achieved through the production of small molecules that are able to freely diffuse across cell membranes. These molecules (autoinducers) can subsequently be detected by other individuals in the population and once a threshold limit is reached, then this may cause a change in gene expression which allows bacteria to coordinate their activities such as biofilm formation, virulence and antibiotic resistance. Despite the widespread interest in QS from molecular mechanisms to social evolution and pathogen control, there is still controversy over the basic evolutionary function of QS. Using Julia as the agent-based modeling platform, we have been able to investigate the rewards and risks of coordination and cooperation in QS. In this talk, I will briefly introduce the research background and share some of our results obtained from in silico evolution using Julia. This work is important as it sheds light on how simple signal-mediated behavioral rules can shape complex collective behaviors in bacteria. Julia greatly helped simplify the modeling precess and speed up simulations.

avatar for Yifei Wang

Yifei Wang

Research Scientist, Georgia Institute of Technology
Yifei Wang is currently a postdoctoral research fellow with the School of Biological Sciences at Georgia Institute of Technology. His research focuses on collective intelligence, evolutionary dynamics and high-performance computing. Dr. Wang received a degree of B.Eng. in computer... Read More →

Friday June 23, 2017 2:30pm - 2:42pm PDT
East Pauley Pauley Ballroom, Berkeley, CA